教育经历
- 2006-2011，韩国庆尚大学应用生命科学部，环境生命科学，博士
- 2004-2006，韩国庆尚大学应用生命科学部，植物分子生物学专业，硕士
- 2000-2004，苏州大学生命科学学院，生物科学（师范）专业，学士
工作经历
- 2022-至今，jk萝莉 ，博士生导师，团队负责人
- 2014-2022，美国南卡罗来纳大学，植物病原菌互作，博士后研究员
- 2011-2014，韩国庆尚大学，WCU植物细胞间通讯, 高级研究员
研究内容
- 1. 水杨酸信号转导和系统获得抗性
- 2. 病原菌效应蛋白
- 3. 环境-植物-病原菌互作
论文
- HUAN CHEN-ORCID: 0000-0003-1182-3144
- HUAN CHEN - Google Scholar: //scholar.google.com/citations?user=uj76wkEAAAAJ&hl=en
- 1. Li K, Qiao Y, Chen H*, Liu F* (2025). Small molecules unlock broad-spectrum plant resistance. Nature Plants, Jan;11(1):11-13. News & Views (*Co-corresponding author)
- 2. Ikram AU, Islam F, Ahmed S, Ling T, Feng F, Sun Z*, Chen H*, Chen J* (2025). All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants. Advances Science, Feb;12(5):e2412223. Review (*Co-corresponding author)
- 3. Zhang M, Zhao X, Li Cheng*, Chen H*, Liu F* (2025) Regulated activation of helper NLRs triggers cell death. Molecular Plant Apr 25:S1674-2052. Spotlight (*Co-corresponding author)
- 4. Ikram AU, Chen H*, Chen J* (2025). H2O2 sulfenylates CHE to activate systemic acquired resistance. Trends in Plant Science, Mar;30(3):238-240. Spotlight (*Co-corresponding author)
- 5. Liu W*, Chen H*, Ma C, Huang L (2025). Decoding citrus Huanglongbing resistance and AI-driven innovation in bacterial pathogen control. J Integr Plant Biol. Commentary (*Co-first author).
- 6. Ikram AU, Xin K, Chen G*, Chen H*, Chen J (2025). Erucamide provides broad-spectrum bacterial resistance through targeting type III secretion system. New Plant Protection. (*Co-corresponding author)
- 7. Khan M, Islam F, Chen H*, Chen J* (2025). A fungal effector hijacks a plastid protein to dampen plant immunity; PR1 is here for rescue. Stress Biology. (5:23). Letter (*Co-corresponding author)
- 8. Zhu F, Li K, Cao M, Zhang Q, Zhou Y, Chen H, Alkhazindar M, Ji Z (2025). NbNAC1 enhances plant immunity against TMV by regulating isochorismate synthase 1 expression and the SA pathway. Plant Journal, Feb;121(4):e17242.
- 9. Ikram AU, Jing Y, Chen H*, Chen J* (2025). Two paths, one goal: mechanism of calcium homeostasis to balance plant growth and immunity. Science China Life Sciences, Jan;68(1):306-308. (*Co-corresponding author)
- 10. Ikram AU, Jing Y, Chen H*, Chen J* (2024). Bacteria deploy water channels to aid infection in plants. Trends in Plant Science, Jun;29(6):620-622. Spotlight (*Co-corresponding author)
- 11. Zhu F, Cao MY, Zhang QP, Mohan R, Schar J, Mitchell M, Chen H, Liu F, Wang D, Fu ZQ (2024). Join the green team: Inducers of plant immunity in the plant disease sustainable control toolbox. Journal of Advanced Research, Mar:57:15-42.
- 12. Zhu F*, Wang XW, Chen H*, Wen J* (2024). Chiral nanopesticides: the invincible opponent of plant viruses. Trends in Plant Science, Feb;29(2):120-122. Spotlight (*Co-corresponding author).
- 13. Wang Y, Risteski P, Yang Y, Chen H, Droby G, Walens A, Jayaprakash D, Troester M, Herring L, Chernoff J, Tolic IM, Bower J, Vaziri C (2023). The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation. Nucleic Acids Research, Oct 27;51(19):10568-10589.
- 14. Islam F, Liu S, Chen H*, Chen J* (2023). Reprogramming of hormone-mediated antiviral responses in plants by viruses: A molecular tug of war on the salicylic acid-mediated immunity. Molecular Plant. Oct 2;16(10):1493-1495. Spotlight (*Co-corresponding author).
- 15. Chen H, Chen J, Zhao Y, Liu F, Fu ZQ (2022). Pseudomonas syringae pathovars. Trends in Microbiology, Sep;30(9):912-913. (IF 18.230).
- 16. Chen H, Li M, Qi G, Zhao M, Wang D, Liu F, Fu ZQ (2021). Two interacting transcriptional coactivators NPR1 and EDS1 cooperatively control plant immune responses. Science Advances, Nov 5;7(45): eabl7173. (IF 14.957).
- 17. Qi G, Chen H, Zheng H, Tang X, Chen J, Wang Y, Bai MY, Liu F, Wang D, Fu ZQ (2021). The BZR1-EDS1 module coordinates plant growth-defense coordination. Molecular Plant, Dec 6;14(12):2072-2087.. (IF 21.949).
- 18. Chen H, Chen J, Li M, Chang M, Xu K, Shang Z, Zhao Y, Palmer IA, Zhang Y, McGill J, Alfano JR, Nishimura MT, Liu F, Fu ZQ (2017). A Bacterial type III effector targets the master regulator of salicylic acid signaling NPR1 to subvert plant immunity. Cell Host & Microbe, Dec 13;22(6):777-788.e7. (IF 31.316).
- #Featured by the F1000Prime Faculty (Frank White, 2018): Recommended as a new finding, good for teaching and interesting hypothesis article.
- #Highlighted in “NPR1 in JazzSet with Pathogen Effectors” (Sun et al., 2018), Trends in Plant Science.
- 19. Liu L, Li Y, Xu Z, Chen H, Zhang J, Manion B, Liu F, Zou L, Fu ZQ, Chen G (2022). The Xanthomonas type III effector XopAP prevents stomatal closure by interfering with vacuolar acidification. J. Integr. Plant Biol. (IF 9.106).
- 20. Liu N, Chen H, Wang X, Wang D, Fu ZQ (2022). TIRggering cell death via two enzymatic reactions. Molecular Plant 15(8): 1263-1265. Spotlight. (IF 21.949).
- 21. Chang M, Chen H, Liu F, Fu ZQ (2022). PTI and ETI: convergent pathways with diverse elicitors. Trends Plant Science. Spotlight. (IF 22.102).
- 22. Chen J, Chen H, Liu F, Fu ZQ (2022). A war on the cell wall. Molecular Plant. Spotlight. (IF 13.164).
- 23. Khan MSS, Islam F, Chen H, Chang M, Wang D, Liu F, Fu ZQ, Chen J (2022). Transcriptional coactivators: Driving Force of Plant Immunity. Front. Plant Sci. Review (IF 6.627).
- 24. Chen J*, Zhang J, Kong M, Freeman A, Chen H*, Liu F* (2021). More stories to tell: NONEXPRESSOR OF PATHOGENESIS RELATED GENES1, a salicylic acid receptor. Plant Cell & Environment: 44(6):1716-1727. (*Co-corresponding author). Review (IF 7.947).
- 25. Meng F, Yang C, Cao J, Chen H, Pang J, Zhao Q, Wang Z, Fu ZQ, Liu J (2020). A bHLH transcription activator regulates defense signaling by nucleo-cytosolic trafficking in rice. J. Integr. Plant Biol. 62(10), 1552-1573. (IF 9.106).
- 26. Chen H, Liu F, Fu ZQ (2019). Deceiving the chaperone. Nature Plants Nov;5(11):1110-1111. News & views. (IF 17.352).
- 27. Chen H, Clinton M, Qi G, Wang D, Liu F, Fu ZQ (2019). Connecting the Dots: a new and complete salicylic acid biosynthesis pathway. Molecular Plant 12(12): 1539-1541. Spotlight. (IF 21.949).
- 28. Palmer IA, Chen H, Chen J, Chang M, Li M, Liu F, Fu ZQ (2019). Novel salicylic acid analogs induce a potent defense response in Arabidopsis. Int J. Mol. Sci 20(13):3356. (IF 6.208).
- 29. Chen J, Mohan R, Zhang Y, Li M, Chen H, Palmer IA, Chang M, Qi G, Spoel SH, Mengiste T, Wang D, Liu F, Fu ZQ (2019). NPR1 promotes its own and target gene expression in plant defense by recruiting CDK8. Plant Physiol. pp.00124. (IF 8.005).
- 30. Chang M, Zhao J, Chen H, Li G, Chen J, Li M, Palmer IA, Song J, Alfano JR, Liu F, Fu ZQ (2019). PBS3 protects EDS1 from proteasome-mediated degradation in plant immunity. Molecular Plant 12(5):678-688. (IF 21.949).
- 31. Chen H, Palmer I, Chen J, Thompson S, Liu F, and Fu Z.Q (2018). Specific and accurate detection of the citrus greening pathogen Candidatus liberibacter spp. using conventional PCR on citrus leaf tissue samples. JOVE. (IF 1.424).
- 32. Li M, Chen H, Chen J, Chang M, Palmer IA, Gassmann W, Liu F, Fu ZQ (2018). TCP transcription factors interact with NPR1 and contribute redundantly to systemic acquired resistance. Front Plant Sci. 14;9:1153. (IF 6.627).
- 33. Qi G, Chen J, Chang M, Chen H, Hall K, Korin J, Liu F, Wang D, Fu ZQ (2018). Pandemonium breaks out: Disruption of salicylic acid-mediated defense by plant pathogens. Molecular Plant 11(12):1427-1439. Review (IF 21.949).
- 34. Wu L*, Chen H*, Curtis C, Fu ZQ (2014). Go in for the kill. How plants deploy effector-triggered immunity to combat pathogens. Virulence 5:7, 1012. (*Co-first author). (IF 5.428).
- 35. Chen H, Ahmad M, Rim Y, Lucas WJ, Kim JY (2013). Evolutionary and molecular analysis of Dof transcription factors identified a conserved motif for intercellular protein trafficking. New Phytologist, Jun;198(4):1250-1260. (IF 10.323).
- 36. Chen H, Jackson D, Kim JY (2014). Identification of evolutionarily conserved amino acid residues in homeodomain of KNOX proteins for intercellular trafficking. Plant Signaling & Behavior 9:e28355. (IF 2.734).
- 37. Kumar D, Chen H, Rim Y, Kim JY (2015). GAL4 transactivation-based assay for the detection of selective intercellular protein movement. Plasmodesmata. Methods Mol Biol. 1217:231-43. Method (IF 1.187).
- 38. Han X, Kumar D, Chen H, Wu S, Kim JY (2014). Transcription factor-mediated cell-to-cell signaling and its regulation. J Exp Bot. 65:1737-49. Review (IF 7.298). Q1-1
- 39. Ahmad M, Rim Y, Chen H, Kim JY (2013). Functional characterization of Arabidopsis Dof transcription factor AtDof4.1. Russ. J. Plant Physiol. 60: 116-123. (IF 1.419). Q3-4
- 40. Je J, Chen H, Song C, Lim CO (2014). Arabidopsis DREB2C modulates ABA biosynthesis during germination. Biochem Biophys Res Commun 452:91-98. (IF 3.322).
- 41. Chen H, Je J, Song C, Hwang JE, Lim CO (2012). A proximal promoter region confers tissue-specific expression of Arabidopsis DREB2C under heat stress. J Integr Plant Biol. Sep;54(9):640-51. (Cover Story). (IF 7.061).
- 42. Chen H, Hwang JE, Lim CJ, Kim DY, Lee SY, Lim CO (2010). Arabidopsis DREB2C functions as a transcriptional activator of HsfA3 during the heat stress response. Biochem Biophys Res Commun. Oct 15;401(2):238-44. (IF 3.322).
- 43. Hwang JE, Lim CJ, Chen H, Je J, Song C, Lim CO (2011). Overexpression of Arabidopsis dehydration responsive element binding protein 2C confers tolerance to oxidative stress. Mol Cells 33: 1-10. (IF 4.250).
- 44. Hwang JE, Hong JK, Lim CJ, Chen H, Je J, Yang KA, Kim DY, Choi Y., Lee SY, Lim CO (2010). Distinct expression patterns of two Arabidopsis phytocystain genes, AtCYS1 and AtCYS2, during development and abiotic stress. Plant Cell Rep 29: 905-915. (IF 4.964).
- 45. Lim CJ, Hwang JE, Chen H, Hong JK, Yang KA, Choi MS, Lee KO, Chung WS, Lee SY, Lim CO (2007). Over-expression of the Arabidopsis DRE/CRT-binding transcription factor DREB2C enhances thermotolerance. Biochem Biophys Res Commun. 362: 431-436. (IF 3.322).
- 46. Gu QY, Shen SD, Xiang WY, Chen H (2005). Studies on the solid culture of somatic cells from Porphyra haitanensis. J Suzhou Univ (Nat Sci) 21(3).
- 47. Li K, Luo L, Chen H, Wang D, Liu F, Fu, ZQ (2025). Three key steps complete the biosynthesis of phenylalanine-derived salicylic acid in diverse plant species. Molecular Plant. Spotlight.
学术活动
- 主要从事植物与病原菌互作及激素调控植物免疫的研究。探究病原菌分泌的毒性蛋白在植物体内操控和抑制宿主免疫系统及生理活动，干扰细胞活动并最终引发病害的机理。在（1）植物病原细菌三型效应子作用免疫性机理、免疫关键调节因子调控水杨酸等防御激素信号转导机制，（2）非细胞自主性转录因子参与细胞间转运的分子进化机制，（3）以及植物响应高温胁迫的调控机制等方面开展了创新性工作并取得了一系列重要成果。
- 实验室将基于以上研究内容并综合运用分子遗传学、细胞生物学、生物化学等手段继续深入探索病原菌-植物-环境间的病害三角关系，解析病原菌致病机理及植物防御和抗病机制。近年来以第一和通讯作者身份在Cell Host & Microbe, Science Advances, New Phytologist, J Integr Plant Biol (封面)，Biochem Biophys Res Commun, Plant Signal Behav, Trends in Microbiology, Molecula
社会兼职
- Molecular Plant-Microbe Interactions（Associate Editor, 编委）
- Plant Biotechnology Journal（Associate Editor, 副主编）
- Frontier in Microbiology (Reviewer Editor) Reviewer Editor
- Stress Biology（客座编辑）
获奖
- 2023年，上海市海外高层次人才
- 2013年，韩国庆尚大学杰出青年研究员奖
- 2010年，韩国生命科学学会暨国际学术研讨会最佳海报奖
- 2004年，苏州大学三好学生和优秀毕业生
- 2004年，苏州大学朱敬文奖学金
- 2004年，苏州大学人民综合一等奖学金