研究内容
- 植物预计能合成约100万的天然代谢小分子。这些小分子不仅是植物和外界交流的“语言”，也是它们抵抗逆境的“生化武器”。同时，它们也组成了我们人类生活中不可或缺的“营养”，“药材”和“能源”等的天然材料来源。我们研究组整合植物基因组，转录组，蛋白组和代谢组等多组学研究手段，探索植物次生代谢小分子的（1）合成与（2）运输，（3）多样性的分子进化机制，（4）以及运用合成生物学的手段，合成低价，优质的植物天然产物。
专利著作
- Wenbing Su#, Yi Jing#, Shoukai Lin#, Zhen Yue#, Xianghui Yang#, Jiabao Xu, Jincheng Wu, Zhike Zhang, Rui Xia, Jiaojiao Zhu, Ning An, Haixin Chen, Yanping Hong, Yuan Yuan, Ting Long, Ling Zhang, Yuanyuan Jiang, Zongli Liu, Hailan Zhang, Yongshun Gao, Yuexue Liu, Hailan Lin, Huicong Wang, Levi Yant, Shunquan Lin* and Zhenhua Liu*. Polyploidy underlies co-option and diversification of biosynthetic triterpene pathways in the apple tribe. PNAS. 118.20 (2021): e2101767118.
- Shicheng Zou#, Jincheng Wu#, Muhammad Qasim Shahid, Yehua He, Shunquan Lin, Zhenhua Liu* & Xianghui Yang*. Identification of key taste components in loquat using widely targeted metabolomics. Food Chemistry, //doi.org/10.1016/j.foodchem.2020.126822 (2020)
- Zhenhua Liu#, Jitender Cheema, Marielle Vigouroux, Lionel Hill, James Reed, Pirita Paajanen, Levi Yant and Anne Osbourn*. Formation and diversification of a paradigm biosynthetic gene cluster in plants. Nature Communications. 2020 Oct;11(1) 5354. doi:10.1038/s41467-020-19153-6.
- Zhenhua Liu#, Hernando G. Suarez Duran#, Yosapol Harnvanichvech, Michael J. Stephenson, M. Eric Schranz, David Nelson, Marnix H. Medema* and Anne Osbourn*. Drivers of metabolic diversification: How dynamic genomic neighborhoods generate new biosynthetic pathways in the Brassicaceae. New Phytologist, doi: 10.1111/nph.16338 (2019)
- Zhenhua Liu#, Raquel Tavarez, Evan S. Forsythe, Francois André, Raphaël Lugan, Gabriella Jonasson, Stéphanie Boutet Mercey, Takayuki Tohge, Mark Beilstein, Danièle Werck-Reichhart*, Hugues Renault. Evolutionary interplay between sister cytochrome P450 genes shapes plasticity in plant metabolism. Nature Communications. 7, 13026 doi: 10.1038/ncomms13026 (2016).
- Zhenhua Liu#, Benoît Boachon, Raphaël Lugan, Raquel Tavares, Mathieu Erhardt, Jérôme Mutterer, Valérie Demais, Stéphanie Pateyron, Véronique Brunaud, Toshiyuki Ohnishi, Ales Pencik, Patrick Achard, Fan Gong, Peter Hedden, Danièle Werck-Reichhart*, Hugues Renault. A conserved cytochrome P450 evolved in seed plants regulates flower maturation. Molecular Plant. 10.1016/j.molp.2015.09.002 (2015).
- Zhenhua Liu#, Wenjie Bao, Wanqi Liang, Jingyuan Yin, Dabing Zhang*. Identification of gamyb-4 and analysis of the regulatory role of GAMYB in rice anther development. Journal of Integrative Plant Biology. 52, 670-678. (2010).