研究内容
- 本课题组聚焦植物天然产物合成途径调控与营养强化，植物表皮毛为靶标品质改良，基于植物合成生物学研究范式，综合运用分子生物学、基因组学、转录组学、代谢组学、生物化学、基因编辑、多基因组装等相关技术和方法，开展植物合成生物学底盘改良，天然产物元件挖掘与设计、代谢通路模块装配集成与重构，天然产物转录调控，植物与环境互作耐逆等方面研究，最终实现植物高附加值天然产物品质的提升及植物耐逆品质的提升。
承担项目
- 国家自然科学青年基金，项目编号：31600231 (主持), “甲基茉莉酸响应的bHLH类转录因子在青蒿素生物合成中的调控机制研究”. 01/2017- 12/2019
- 中国博士后科学基金一等资助，项目编号：2016M590356 (主持), “MYC类转录因子调控青蒿素生物合成的机制研究”. 05/2016- 08/2019
- 国家重大新药创制科技重大专项资助课题，项目编号：2017ZX09101002-003-002 (参与), “高产青蒿素的黄花蒿优良品系代谢工程育种研究” 01/2017-12/2020.
- 国家高技术研究发展（863）计划，项目编号：2011AA100605 (参与), “植物代谢产物生物反应器产品研发” 01/2011-12/2016
- Bill & Melinda Gates Foundation，项目编号：OPP1199872 (参与) ，“Identification and functional characterization of putative enzymes involved in the artemisinin biosynthesis from Artemisia annua”。09/2018-12/2019
论文
- Li M, Fu Y, Liang X, Liu X, Huang L, Zhang S, Zhang W, Tang K, Shen Q*. (2025). SlHDZIV3 and SlHDZIV9 are two positive regulators in the formation of tomato trichomes. Plant, Cell & Environment 48: 5789-5801.
- Liu, X., Fu, Y., Li, M., Xiong, S., Huang, L., Zhang, S., Zhang, W., Liang, X., Wang, W., Tang, K. and Shen, Q*. (2025). Biofortification of tomatoes with beta-carotene through targeted gene editing. International Journal of Biological Macromolecules 327: 147396.
- Zhang W, Fu Y, Li M, Zhang S, Zhang Y, Liu X, Huang L, Liang X, Shen Q*. (2025). SlWRKY75 functions as a differential regulator to enhance drought tolerance in tomato (Solanum lycopersicum L.). Plant Physiology and Biochemistry 227: 110189.
- Fu Y, Li M, Zhang W, Liu X, Huang L, Zhang S, Liang X, Zhang L, Tang K, Rose JKC, Shen Q*. (2025). The role, regulation and application of plant fruit trichomes. Molecular Horticulture 5: 41.
- Liu X, Huang L, Li M, Fu Y, Zhang W, Zhang S, Liang X, Shen Q*. (2025). An efficient and cost-effective novel strategy for identifying CRISPR-Cas-mediated mutants in plant offspring. The CRISPR Journal 8: 26-36.
- Kayani S-I, Rahman S-u, Shen Q, Cui Y, Liu W, Hu X, Zhu F, Huo S*. (2024). Molecular approaches to enhance astaxanthin biosynthesis; future outlook: engineering of transcription factors in Haematococcus pluvialis. Critical Reviews in Biotechnology 44: 514-529.
- Kayani S-I, Ma Y, Fu X, Shen Q, Li Y, Rahman S-u, Peng B, Huang L, Tang K*. (2023). JA-regulated AaGSW1-AaYABBY5/AaWRKY9 complex regulates artemisinin biosynthesis in Artemisia annua. Plant and Cell Physiology 64: 771-785.
- Shen Q*, Huang H, Xie L, Hao X, Kayani S-I, Liu H, Qin W, Chen T, Pan Q, Liu P et al. (2022). Basic helix-loop-helix transcription factors AabHLH2 and AabHLH3 function antagonistically with AaMYC2 and are negative regulators in artemisinin biosynthesis. Frontiers in Plant Science 13: 885622.
- Kayani S-I, Shen Q, Rahman S-u, Fu X, Li Y, Wang C, Hassani D, Tang K*. (2021). Transcriptional regulation of flavonoid biosynthesis in Artemisia annua by AaYABBY5. Horticulture Research 8: 257.
- Ma Y-N, Xu D, Yan X, Wu Z-K, Kayani S-I, Shen Q, Fu X, Xie L, Hassani D, Li L et al. (2021). Jasmonate- and abscisic acid-activated AaGSW1-AaTCP15/AaORA transcriptional cascade promotes artemisinin biosynthesis in Artemisia annua. Plant Biotechnology Journal 19: 1412-1428.
- Hassani, D., Fu, X., Shen, Q., Khalid, M., Rose, J.K.C., and Tang, K. (2020). Parallel Transcriptional Regulation of Artemisinin and Flavonoid Biosynthesis. Trends in Plant Science 25, 466-476.
- Shen Q, Huang H, Zhao Y, Xie L, He Q, Zhong Y, Wang Y, Wang Y, Tang k. (2019). The transcription factor AabZIP9 positively regulates the biosynthesis of artemisinin in Artemisia annua. Frontiers in Plant Science 10:1294.
- Kayani S, Shen Q, Ma Y, Fu X, Xie L, Zhong Y, Chen T, Pan Q, Li L, Rahman S, et al. (2019). The YABBY family transcription factor AaYABBY5 directly targets cytochrome P450 monooxygenase (CYP71AV1) and double bond reductase 2 (DBR2) involved in artemisinin biosynthesis in Artemisia annua. Frontiers in Plant Science 10: 1084.
- Lv Z, Guo Z, Zhang L, Zhang F, Jiang W, Shen Q, Fu X, Yan T, Shi P, Hao X, et al. (2019). Interaction of AaTGA6 with salicylic acid signaling modulates artemisinin biosynthesis in Artemisia annua. Journal of Experimental Botany 70(15):3969-3979.
- Shen Q#, Zhang L#, Liao Z#, Wang S, Yan T, Shi P, et al. (2018). The genome of Artemisia annua provides insight into the evolution of Asteraceae family and artemisinin biosynthesis. Molecular Plant 11(6): 776-788.
- Ma Y, Xu D, Li L, Zhang F, Fu X, Shen Q, Lyu, Wu Z, Pan Q, Shi P et al. (2018) Jasmonate promotes artemisinin biosynthesis by activating the TCP14-ORA complex in Artemisia annua. Science Advances 2018, 4(11):eaas9357.
- Chen M, Yan T, Shen Q, Lu X, Pan Q, Huang Y, Tang Y, Fu X, Liu M, Jiang W, et al. (2017). GLANDULAR TRICHOME-SPECIFIC WRKY 1 promotes artemisinin biosynthesis in Artemisia annua. New Phytologist 214(1): 304-316.
- Shi P, Fu X, Shen Q, Liu M, Pan Q, Tang Y, Jiang W, Lv Z, Yan T, Ma Y, et al. (2017). The roles of AaMIXTA1 in regulating the initiation of glandular trichomes and cuticle biosynthesis in Artemisia annua. New Phytologist 217(1): 261-276.
- Yan T, Chen M, Shen Q, Li L, Fu X, Pan Q, Tang Y, Shi P, Lv Z, Jiang W, et al. (2017). HOMEODOMAIN PROTEIN 1 is required for jasmonate‐mediated glandular trichome initiation in Artemisia annua. New Phytologist 213(3): 1145-1155.
- Shen Q#, Lu X#, Yan T, Fu X, Lv Z, Zhang F, Pan Q, Wang G, Sun X, Tang K*. (2016). The jasmonate-responsive AaMYC2 transcription factor positively regulates artemisinin biosynthesis in Artemisia annua. New Phytologist 210(4): 1269-1281.（ESI高被引论文）
- Shen Q, Yan T, Fu X, Tang K. (2016). Transcriptional regulation of artemisinin biosynthesis in Artemisia annua L. Science Bulletin 61(1): 18-25. (封面论文)
- Tang K, Shen Q, Lu X, Zhang F. (2016). Improving artemisinin content in Artemisia annua by transcription factor regulation. Pushing the boundaries of scientific research: 120 years of addressing global issues (Science/AAAS, Washington, DC, 2016) This is a sponsored supplement. Science 351(6278): p.48-51.
专利著作
- 一种青蒿bHLH类转录因子编码序列及克隆方法与应用，发明人：唐克轩、沈乾、赵彧、张婷婷、孙小芬，授权日：2020.03.06，专利号：ZL 201610680590.6
- 一种青蒿WRKY类转录因子编码序列及克隆方法与应用，发明人：唐克轩、沈乾、王蕾、江伟民、郝小龙、黎凌，授权日：2020.02.07，专利号：ZL 201610682275.7
- 一种青蒿bHLH类转录因子编码序列及克隆方法与应用，发明人：唐克轩、沈乾、赵彧、王玉亮，授权日：2020.02.07，专利号：ZL 201610680603.X
- 一种青蒿bZIP类转录因子编码序列及克隆方法与应用，发明人：唐克轩、沈乾、黄华仪、颜廷祥、陈明慧、何倩，授权日：2019.11.26，专利号：ZL 201610682249.4
- 一种青蒿bZIP类转录因子编码序列及克隆方法与应用，发明人：唐克轩、沈乾、马亚男、吕宗友、潘琪芳、唐岳立，授权日：2019.12.10，申请号：ZL 201610680529.1
- 一种青蒿bZIP类转录因子编码序列及克隆方法与应用，发明人：唐克轩、沈乾、赵彧、付雪晴、石璞、刘萌，授权日：2019.11.26，专利号：ZL 201610680579.X
- 一种青蒿MYC2转录因子蛋白编码序列及其应用，发明人：唐克轩、沈乾、陆续、付雪晴、颜廷祥、孙小芬、王国丰，授权日：2015.09.30，专利号：ZL 201310413155.3
- 转DBR2基因提高青蒿中青蒿素含量的方法，发明人：唐克轩、沈乾、陈韵斐、王涛、吴韶龑、陆续，授权日：2015.07.08，专利号：ZL 201210014227.2
- 一种调控基因在非分泌型腺毛中表达的启动子及其应用，发明人：唐克轩、陈俏、沈乾、付雪晴、石璞、孙小芬、颜廷祥，授权日：2017.12.29，专利号：ZL 201510727603.6
- 一种调控基因在非分泌型腺毛中表达的启动子及其应用，发明人：唐克轩、陈俏、沈乾、付雪晴、石璞、孙小芬、颜廷祥，授权日：2017.11.10，专利号：ZL 201510729014.1
社会兼职
- Frontiers in Plant Science, Plant Metabolism and Chemodiversity Section Associate Editor 2019-10
- Horticulturae Editorial Board Member 2024-12